TY - JOUR
AU - Rêgo JL
AU - Santana NDL
AU - Aguiar ER
AU - Queiroz IS
AU - de Carvalho LP
AU - Machado P
AU - Castellucci LC
AB - Introduction:<br>
The development of leprosy reactions is one of the main challenges in the management of patients with leprosy. The reactions can be divided into type 1 (RR) and type 2 (ENL), representing comorbidities that can cause nerve damage and disability. This study aimed to correlate the production of immunological markers in the serum of leprosy patients with and without reactions.
<br><br>
Methods:<br>
Cytokines and chemokines were measured in serum by sandwich ELISA in a cross-section of 69 leprosy patients: 24 without evidence of reactions (NR), 23 with RR and 22 with ENL.
<br><br>
Results:<br>
We identified an increase in CXCL-9 and CXCL-10 in the multibacillary forms (MB) of leprosy that might have a role in the development of reactions, since both chemokines were positively correlated with the pro-inflammatory cytokine IL-6 in reactional patients. IL-8 was also noted as a marker for reactions and was correlated with TNF and CCL4 in this group. Even in patients without reactions there was a strong correlation between IL-8 and IL-6, which led us to think that the concomitant increase in these two markers in MB patients may signal impending reactions.
<br><br>
Conclusions:<br>
All together, we suggest CXCL-9, CXCL-10, IL-8 and CCL4 as markers for leprosy reaction development, in addition to the interactions with inflammatory cytokines incriminated in MB, such as IL-6 and TNF.
BT - Leprosy Review
DO - 10.47276/lr.91.4.393
IS - 4
LA - eng
N2 - Introduction:<br>
The development of leprosy reactions is one of the main challenges in the management of patients with leprosy. The reactions can be divided into type 1 (RR) and type 2 (ENL), representing comorbidities that can cause nerve damage and disability. This study aimed to correlate the production of immunological markers in the serum of leprosy patients with and without reactions.
<br><br>
Methods:<br>
Cytokines and chemokines were measured in serum by sandwich ELISA in a cross-section of 69 leprosy patients: 24 without evidence of reactions (NR), 23 with RR and 22 with ENL.
<br><br>
Results:<br>
We identified an increase in CXCL-9 and CXCL-10 in the multibacillary forms (MB) of leprosy that might have a role in the development of reactions, since both chemokines were positively correlated with the pro-inflammatory cytokine IL-6 in reactional patients. IL-8 was also noted as a marker for reactions and was correlated with TNF and CCL4 in this group. Even in patients without reactions there was a strong correlation between IL-8 and IL-6, which led us to think that the concomitant increase in these two markers in MB patients may signal impending reactions.
<br><br>
Conclusions:<br>
All together, we suggest CXCL-9, CXCL-10, IL-8 and CCL4 as markers for leprosy reaction development, in addition to the interactions with inflammatory cytokines incriminated in MB, such as IL-6 and TNF.
PB - Lepra
PY - 2020
SP - 393
EP - 402
T2 - Leprosy Review
TI - Serum immune markers as triggers of reactional episodes in multibacillary patients with leprosy
UR - https://leprosyreview.org/admin/public/article_shell/uploads/article_files/Lepra/LEPROSY/91/4/lr2020326/lr2020326.pdf
VL - 91
SN - 2162-8807
ER -