TY - JOUR
KW - Animals
KW - Dapsone
KW - Drug Resistance, Microbial
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Mice, Inbred CBA
KW - Mycobacterium leprae
KW - Philippines
KW - Prevalence
AU - Cruz E
AU - Cellona R V
AU - Balagon M V
AU - Villahermosa L G
AU - Fajardo T T
AU - Abalos R M
AU - Tan E V
AU - Walsh G P
AB - <p>At a time when primary dapsone resistance was prevalent in many leprosy endemic areas, Cebu in The Philippines reported only 3.6% in the period 1975-1978 and later 8.1% in the period 1979-1982. In our current study of patients in the period 1988-1992, the number increased dramatically to 52.7%. In addition, 7.9% of the isolates are highly resistant to dapsone, a level of resistance not seen in earlier studies. This finding could have severe ramifications to the World Health Organization's multidrug therapy (WHO-MDT) mode of treatment, where dapsone is one of the principal drugs. Moreover, the increase in primary dapsone resistance may be a contributing factor in the recent finding that there has been no decline in the number of new cases found in Cebu, even after the implementation of WHO-MDT in 1985. There is a need for new drugs that could be included in the multidrug treatment for multibacillary and paucibacillary leprosy.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8862258?dopt=Abstract
DA - 1996 Sep
IS - 3
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>At a time when primary dapsone resistance was prevalent in many leprosy endemic areas, Cebu in The Philippines reported only 3.6% in the period 1975-1978 and later 8.1% in the period 1979-1982. In our current study of patients in the period 1988-1992, the number increased dramatically to 52.7%. In addition, 7.9% of the isolates are highly resistant to dapsone, a level of resistance not seen in earlier studies. This finding could have severe ramifications to the World Health Organization's multidrug therapy (WHO-MDT) mode of treatment, where dapsone is one of the principal drugs. Moreover, the increase in primary dapsone resistance may be a contributing factor in the recent finding that there has been no decline in the number of new cases found in Cebu, even after the implementation of WHO-MDT in 1985. There is a need for new drugs that could be included in the multidrug treatment for multibacillary and paucibacillary leprosy.</p>
PY - 1996
SP - 253
EP - 6
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Primary dapsone resistance in Cebu, The Philippines; cause for concern.
UR - http://ila.ilsl.br/pdfs/v64n3a01.pdf
VL - 64
SN - 0148-916X
ER -