TY - JOUR
KW - Adenosine Triphosphate
KW - Animals
KW - Chromatography, High Pressure Liquid
KW - Dapsone
KW - Drug Interactions
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Microbial Sensitivity Tests
KW - Mycobacterium leprae
KW - Receptors, Fc
KW - Thymidine
KW - Trimethoprim
AU - Seydel J K
AU - Wempe E G
AU - Rosenfeld M
AU - Jagannathan R
AU - Mahadevan P R
AU - Dhople A M
AB - <p>The antibacterial effect of brodimoprim alone and in combination with dapsone has been studied in vitro in cell-free systems and in whole mycobacterial cells as well as in vivo in mice and humans. The obtained inhibitory effects in vitro and in vivo against model mycobacterial strains and M. leprae, the pharmacokinetic properties in human and its synergistic effect with the most used drug in the chemotherapy of leprosy, dapsone, make brodimoprim a promising candidate in the therapy of leprosy.</p>
BT - Arzneimittel-Forschung
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2187440?dopt=Abstract
DA - 1990 Jan
IS - 1
J2 - Arzneimittelforschung
LA - eng
N2 - <p>The antibacterial effect of brodimoprim alone and in combination with dapsone has been studied in vitro in cell-free systems and in whole mycobacterial cells as well as in vivo in mice and humans. The obtained inhibitory effects in vitro and in vivo against model mycobacterial strains and M. leprae, the pharmacokinetic properties in human and its synergistic effect with the most used drug in the chemotherapy of leprosy, dapsone, make brodimoprim a promising candidate in the therapy of leprosy.</p>
PY - 1990
SP - 69
EP - 75
T2 - Arzneimittel-Forschung
TI - In vitro and in vivo experiments with the new inhibitor of mycobacterium leprae brodimoprim alone and in combination with dapsone.
VL - 40
SN - 0004-4172
ER -