PGL-1 epitope bearing a -aminoethylphenol group was efficiently synthesized by using linear synthetic routes. A method for efficient synthesis of oligosaccharides containing rhamnose rings was developed. The chemistry is flexible and could be used for the synthesis of other PGLs antigens. A biotinylated PGL-1 antigen was synthesized and could be used as a probe for early detection of leprosy.
BT - The Journal of organic chemistry C1 - https://www.ncbi.nlm.nih.gov/pubmed/32806098 DA - 08/2020 DO - 10.1021/acs.joc.0c01088 IS - 16 J2 - J. Org. Chem. LA - eng N2 -PGL-1 epitope bearing a -aminoethylphenol group was efficiently synthesized by using linear synthetic routes. A method for efficient synthesis of oligosaccharides containing rhamnose rings was developed. The chemistry is flexible and could be used for the synthesis of other PGLs antigens. A biotinylated PGL-1 antigen was synthesized and could be used as a probe for early detection of leprosy.
PY - 2020 SP - 10973 EP - 10979 T2 - The Journal of organic chemistry TI - Chemical Synthesis of the Trisaccharide Epitope of Phenolic Glycolipid-1 Surface Antigen from Mycobacterium leprae. VL - 85 SN - 1520-6904 ER -