TY - JOUR
KW - Animals
KW - Disease Models, Animal
KW - leprosy
KW - Mycobacterium leprae
KW - Tupaia
KW - Tupaiidae
AU - Wang H Y
AU - Liu J H
AU - Ye S Z
AU - Yu L C
AU - Shi M Q
AU - Sang H G
AB - <p>The Tupaia belangeri yunalis (tree shrew) is one of the primitive primates. They were inoculated subcutaneously in the footpad or intravenously with Mycobacterium leprae from a patient with multibacillary leprosy. As controls, the footpads of CFW mice were inoculated with the same suspension of M. leprae. The results showed growth of acid-fast bacilli (AFB) in the footpads of locally inoculated CFW mice and in the footpads of both locally and intravenously inoculated tupaias. Whereas the numbers of AFB declined in the footpads of CFW mice after 12 months, they increased in the tupaia footpads, up to 2.44 x 19(9) AFB/g of tissue. The footpads of one tupaia were swollen, which on section revealed a granulomatous infiltration, including foamy and heavily infected macrophages. M. leprae were also seen in the branches of cutaneous nerves. Also AFB occurred in some viscera. Preliminary studies indicate that the AFB multiplying in tupaias are M. leprae.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2181220?dopt=Abstract
CN - Infolep Library - available
DA - 1990 Mar
IS - 1
J2 - Lepr Rev
LA - eng
N2 - <p>The Tupaia belangeri yunalis (tree shrew) is one of the primitive primates. They were inoculated subcutaneously in the footpad or intravenously with Mycobacterium leprae from a patient with multibacillary leprosy. As controls, the footpads of CFW mice were inoculated with the same suspension of M. leprae. The results showed growth of acid-fast bacilli (AFB) in the footpads of locally inoculated CFW mice and in the footpads of both locally and intravenously inoculated tupaias. Whereas the numbers of AFB declined in the footpads of CFW mice after 12 months, they increased in the tupaia footpads, up to 2.44 x 19(9) AFB/g of tissue. The footpads of one tupaia were swollen, which on section revealed a granulomatous infiltration, including foamy and heavily infected macrophages. M. leprae were also seen in the branches of cutaneous nerves. Also AFB occurred in some viscera. Preliminary studies indicate that the AFB multiplying in tupaias are M. leprae.</p>
PY - 1990
SP - 12
EP - 8
T2 - Leprosy review
TI - Preliminary observations on experimental leprosy in tupaias (Tupaia belangeri yunalis).
UR - http://leprev.ilsl.br/pdfs/1990/v61n1/pdf/v61n1a02.pdf
VL - 61
SN - 0305-7518
ER -