TY - JOUR
AU - Choi H
AU - Cho S
AU - Ha Y
AU - Ocampo B
AU - Park S
AU - Chen S
AU - Bennett C
AU - Han J
AU - Rossner R
AU - Kang J
AU - Lee Y
AU - Park S
AU - Kaeberlein M
AB - <p>The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in  through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in  by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.</p>
BT - Translational medicine of aging
C1 - https://www.ncbi.nlm.nih.gov/pubmed/32190786
DA - 01/2019
DO - 10.1016/j.tma.2019.07.001
J2 - Transl Med Aging
LA - eng
N2 - <p>The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in  through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in  by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.</p>
PY - 2019
SP - 64
EP - 69
T2 - Translational medicine of aging
TI - DDS promotes longevity through a microbiome-mediated starvation signal.
UR - https://www.sciencedirect.com/science/article/pii/S2468501119300045?via%3Dihub
VL - 3
SN - 2468-5011
ER -