Venous leg ulcers (VLUs) are painful, recalcitrant to therapy and represent a significant burden on quality of patients' life and society (1). Therefore, innovative therapies are needed. Recently, the role of the renin-angiotensin system (RAS) in wound healing has been characterized in animal models (2). Given the availability and excellent safety profile of various RAS modulators, successful repurposing of these drugs to improve healing of chronic ulcers may prove useful in clinical settings.
BT - The British journal of dermatology C1 - https://www.ncbi.nlm.nih.gov/pubmed/31778203 DA - 11/2019 DO - 10.1111/bjd.18743 J2 - Br. J. Dermatol. LA - eng N2 -Venous leg ulcers (VLUs) are painful, recalcitrant to therapy and represent a significant burden on quality of patients' life and society (1). Therefore, innovative therapies are needed. Recently, the role of the renin-angiotensin system (RAS) in wound healing has been characterized in animal models (2). Given the availability and excellent safety profile of various RAS modulators, successful repurposing of these drugs to improve healing of chronic ulcers may prove useful in clinical settings.
PY - 2019 T2 - The British journal of dermatology TI - Use of topical Valsartan as a novel treatment of complicated leg ulcers. SN - 1365-2133 ER -