For the first time in Brazil it was investigated the occurrence of IgM anti-PGL-1 in the sera of household contacts of leprosy patients using the ELISA methodology. The sera of the multibacillary patients showed significantly more immuno-reactivity than from the paucibacillary patients. It was observed a high subclinical infection incidence among household contacts (19.4%). The percentage of leprosy development was 5% (1/21) among the seropositive contact group. This finding suggests that serology could be useful as prognostic test, but for better definition is necessary to test a population from endemic area for long period time.
BT - Memorias do Instituto Oswaldo Cruz C1 - http://www.ncbi.nlm.nih.gov/pubmed/2087157?dopt=Abstract DA - 1990 Apr-Jun DO - 10.1590/s0074-02761990000200008 IS - 2 J2 - Mem. Inst. Oswaldo Cruz LA - eng N2 -For the first time in Brazil it was investigated the occurrence of IgM anti-PGL-1 in the sera of household contacts of leprosy patients using the ELISA methodology. The sera of the multibacillary patients showed significantly more immuno-reactivity than from the paucibacillary patients. It was observed a high subclinical infection incidence among household contacts (19.4%). The percentage of leprosy development was 5% (1/21) among the seropositive contact group. This finding suggests that serology could be useful as prognostic test, but for better definition is necessary to test a population from endemic area for long period time.
PY - 1990 SP - 191 EP - 4 T2 - Memorias do Instituto Oswaldo Cruz TI - IgM immunoglobulins reacting with the phenolic glycolipid-1 antigen from Mycobacterium leprae in sera of leprosy patients and their contacts. UR - http://www.scielo.br/pdf/mioc/v85n2/vol85(f2)_053-056.pdf VL - 85 SN - 0074-0276 ER -