In the grey layer of sphagnum vegetation originating from former leprosy-endemic regions of coastal Norway, acid-fast bacilli (AFB) containing Mycobacterium leprae-specific phenolic glycolipid I (PGL-I) on the surface have been found. These AFB survived in foot pads of nude mice with multiplication but without swelling. This contrasts to experimental leprosy with clinically derived M. leprae where swelling and unlimited multiplication takes place. The naturally occurring AFB may be of a lower pathogenicity than M. leprae obtained from clinical cases. The possibility of M. leprae surviving in sphagnum vegetation was assessed by inoculation of clinically derived M. leprae into the grey layer of the sphagnum. It multiplied more than tenfold and retained its pathogenicity in nude mice for 16 weeks, the duration of the experiment. The lack of pathogenicity of sphagnum-derived, M. leprae-like mycobacteria may be relevant to the decline of leprosy in Norway.
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -http://www.ncbi.nlm.nih.gov/pubmed/2142948?dopt=Abstract
DA - 1990 Jun IS - 2 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -In the grey layer of sphagnum vegetation originating from former leprosy-endemic regions of coastal Norway, acid-fast bacilli (AFB) containing Mycobacterium leprae-specific phenolic glycolipid I (PGL-I) on the surface have been found. These AFB survived in foot pads of nude mice with multiplication but without swelling. This contrasts to experimental leprosy with clinically derived M. leprae where swelling and unlimited multiplication takes place. The naturally occurring AFB may be of a lower pathogenicity than M. leprae obtained from clinical cases. The possibility of M. leprae surviving in sphagnum vegetation was assessed by inoculation of clinically derived M. leprae into the grey layer of the sphagnum. It multiplied more than tenfold and retained its pathogenicity in nude mice for 16 weeks, the duration of the experiment. The lack of pathogenicity of sphagnum-derived, M. leprae-like mycobacteria may be relevant to the decline of leprosy in Norway.
PY - 1990 SP - 353 EP - 7 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Acid-fast bacilli found in sphagnum vegetation of coastal Norway containing Mycobacterium leprae-specific phenolic glycolipid-I. UR - http://ila.ilsl.br/pdfs/v58n2a11.pdf VL - 58 SN - 0148-916X ER -