TY - JOUR
KW - Aged
KW - Aged, 80 and over
KW - Clofazimine
KW - Drug Eruptions
KW - Female
KW - Humans
KW - Leprosy, lepromatous
KW - Male
KW - Neuronal Ceroid-Lipofuscinoses
KW - Pigmentation Disorders
KW - Skin
AU - Job C K
AU - Yoder L
AU - Jacobson R R
AU - Hastings R C
AB - <p>Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.</p>
BT - Journal of the American Academy of Dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2145325?dopt=Abstract
DA - 1990 Aug
DO - 10.1016/0190-9622(90)70204-u
IS - 2 Pt 1
J2 - J. Am. Acad. Dermatol.
LA - eng
N2 - <p>Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.</p>
PY - 1990
SP - 236
EP - 41
T2 - Journal of the American Academy of Dermatology
TI - Skin pigmentation from clofazimine therapy in leprosy patients: a reappraisal.
VL - 23
SN - 0190-9622
ER -