TY - JOUR KW - Adolescent KW - Adult KW - Atrophy KW - Child KW - Epidermis KW - Female KW - Follow-Up Studies KW - Humans KW - Lepromin KW - leprosy KW - Leprosy, Tuberculoid KW - Male KW - Nervous System Diseases KW - Pigmentation Disorders KW - Sensation AU - Agarwal U S AU - Handa A K AU - Mathur D AU - Mehta R D AU - Mittal A AU - Dhar N AU - Mathur N K AB -

26 Patients of leprosy presenting with hypopigmented lesions were divided on morphological grounds into 3 Sub groups, Group I (9 patients) with well-defined single patch with moderate to complete sensory loss; Group II (8 patients) with single ill-defined lesion having partial sensory loss; and Group III (9 patients) having multiple hypo-pigmented patches with mild to moderate sensory loss. Epidermal atrophy was a conspicuous histological finding in all groups. Only patients in Group I showed epitheloid cells in dermal infiltrate with erosion of epidermis in one case. This group may be labelled as maculoanesthetic leprosy. Patients in Group II and III showed mononuclear cell infiltrate in dermis, around neurovascular bundles and appendages. They were histologically consistent with indeterminate leprosy. Follow-up biopsy after six to eight months of treatment showed healing of the lesion of reduction in the infiltrate in most cases.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/2086675?dopt=Abstract CN - Infolep Library - available DA - 1990 Oct-Dec IS - 4 J2 - Indian J Lepr LA - eng N2 -

26 Patients of leprosy presenting with hypopigmented lesions were divided on morphological grounds into 3 Sub groups, Group I (9 patients) with well-defined single patch with moderate to complete sensory loss; Group II (8 patients) with single ill-defined lesion having partial sensory loss; and Group III (9 patients) having multiple hypo-pigmented patches with mild to moderate sensory loss. Epidermal atrophy was a conspicuous histological finding in all groups. Only patients in Group I showed epitheloid cells in dermal infiltrate with erosion of epidermis in one case. This group may be labelled as maculoanesthetic leprosy. Patients in Group II and III showed mononuclear cell infiltrate in dermis, around neurovascular bundles and appendages. They were histologically consistent with indeterminate leprosy. Follow-up biopsy after six to eight months of treatment showed healing of the lesion of reduction in the infiltrate in most cases.

PY - 1990 SP - 416 EP - 21 T2 - Indian journal of leprosy TI - Hypopigmented lesions in early leprosy--a clinical and histological study. VL - 62 SN - 0254-9395 ER -