TY - JOUR KW - Animals KW - Combined Modality Therapy KW - Dapsone KW - Drug Therapy, Combination KW - Interferon-gamma KW - leprosy KW - Mice KW - Mice, Nude KW - Recombinant Proteins KW - Rifampin AU - Banerjee D K AU - McDermott-Lancaster R D AB -

The possibility of synergy between immunotherapy with recombinant interferon-gamma (IFN-gamma) and chemotherapy with rifampin (RMP) and dapsone (DDS) against Mycobacterium leprae was examined in nude mice. IFN-gamma alone failed to show any effect on the growth of M. leprae in the nude mouse foot pad. No synergy was demonstrable between DDS, either at 0.0001% or at 0.001%, and IFN-gamma. A subinhibitory level of RMP with IFN-gamma was also ineffective, but RMP at 0.006% with IFN-gamma produced a statistically significant enhancement of killing (26-fold) when compared with RMP at 0.006% only. It should be emphasized, however, that results obtained in the immunodeficient nude mouse model may not be comparable to those which might have been given by lepromatous leprosy patients.

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -

http://www.ncbi.nlm.nih.gov/pubmed/2126271?dopt=Abstract

DA - 1990 Dec IS - 4 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -

The possibility of synergy between immunotherapy with recombinant interferon-gamma (IFN-gamma) and chemotherapy with rifampin (RMP) and dapsone (DDS) against Mycobacterium leprae was examined in nude mice. IFN-gamma alone failed to show any effect on the growth of M. leprae in the nude mouse foot pad. No synergy was demonstrable between DDS, either at 0.0001% or at 0.001%, and IFN-gamma. A subinhibitory level of RMP with IFN-gamma was also ineffective, but RMP at 0.006% with IFN-gamma produced a statistically significant enhancement of killing (26-fold) when compared with RMP at 0.006% only. It should be emphasized, however, that results obtained in the immunodeficient nude mouse model may not be comparable to those which might have been given by lepromatous leprosy patients.

PY - 1990 SP - 690 EP - 6 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Effect of simultaneous administration of interferon-gamma and chemotherapy against Mycobacterium leprae in experimental infection in nude mice. UR - http://ila.ilsl.br/pdfs/v58n4a07.pdf VL - 58 SN - 0148-916X ER -