TY - JOUR KW - Animals KW - Chromosome Mapping KW - Gene Expression Regulation KW - Genes, Dominant KW - Genetic Markers KW - Humans KW - Immunity, Innate KW - leprosy KW - Macrophage Activation KW - Macrophages KW - Mice KW - Mycobacterium Infections KW - Phenotype KW - Tuberculosis AU - Schurr E AU - Malo D AU - Radzioch D AU - Buschman E AU - Morgan K AU - Gros P AU - Skamene E AB -

The Mendelian segregation of resistance to infection in different strains of mice infected with mycobacteria, Salmonella and Leishmania spp, all of which live in macrophages, is currently under close scrutiny. Here, Erwin Schurr and colleagues review the nature and function of the Bcg gene in controlling innate resistance to mycobacterial infection in mice and speculate on the occurrence of a possible human equivalent.

BT - Immunology today C1 - http://www.ncbi.nlm.nih.gov/pubmed/2069678?dopt=Abstract DA - 1991 Mar DO - 10.1016/S0167-5699(05)80012-X IS - 3 J2 - Immunol. Today LA - eng N2 -

The Mendelian segregation of resistance to infection in different strains of mice infected with mycobacteria, Salmonella and Leishmania spp, all of which live in macrophages, is currently under close scrutiny. Here, Erwin Schurr and colleagues review the nature and function of the Bcg gene in controlling innate resistance to mycobacterial infection in mice and speculate on the occurrence of a possible human equivalent.

PY - 1991 SP - A42 EP - 5 T2 - Immunology today TI - Genetic control of innate resistance to mycobacterial infections. VL - 12 SN - 0167-5699 ER -