TY - JOUR
KW - Animals
KW - Dapsone
KW - Drug Resistance, Multiple, Bacterial
KW - Drug Therapy, Combination
KW - Humans
KW - India
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Microbial Sensitivity Tests
KW - Mycobacterium leprae
KW - Rifampin
AU - Gupta U D
AU - Katoch K
AU - Katoch V M
AB - <p>The aim of this study to study the drug resistance patterns of dapsone (pre- and post-MDT) and rifampicin (post-MDT era). All the 84 patients from pre-MDT period (1985-1990) and 77 patients for post-MDT period (1990-2002) reporting to a tertiary care hospital-NJIL & OMD, Agra and referred for drug susceptibility testing were included in the study. Drug resistance was studied by mouse foot pad method. Dapsone resistance was high during pre-MDT era i.e. 8.3% (medium) and 19.1% (high) with an overall dapsone resistance of 27.4%. During the post-MDT era, the dapsone resistance was low i.e. 1.3% (medium) and 3.9% (high) respectively (overall dapsone resistance-5.2%). While no comparison with pre-MDT era is available, the rifampicin resistance in these selected self-reporting cases during the post-MDT era was comparatively rather high (9.1%). MDT appears to have been useful in reducing the prevalence of dapsone resistance in leprosy patients reporting to a tertiary care hospital.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/20509341?dopt=Abstract
CN - Infolep Library - available
DA - 2009 Jul-Sep
DO - 10.1136/bmj.c3651
IS - 3
J2 - Indian J Lepr
LA - eng
N2 - <p>The aim of this study to study the drug resistance patterns of dapsone (pre- and post-MDT) and rifampicin (post-MDT era). All the 84 patients from pre-MDT period (1985-1990) and 77 patients for post-MDT period (1990-2002) reporting to a tertiary care hospital-NJIL & OMD, Agra and referred for drug susceptibility testing were included in the study. Drug resistance was studied by mouse foot pad method. Dapsone resistance was high during pre-MDT era i.e. 8.3% (medium) and 19.1% (high) with an overall dapsone resistance of 27.4%. During the post-MDT era, the dapsone resistance was low i.e. 1.3% (medium) and 3.9% (high) respectively (overall dapsone resistance-5.2%). While no comparison with pre-MDT era is available, the rifampicin resistance in these selected self-reporting cases during the post-MDT era was comparatively rather high (9.1%). MDT appears to have been useful in reducing the prevalence of dapsone resistance in leprosy patients reporting to a tertiary care hospital.</p>
PY - 2009
SP - 131
EP - 4
T2 - Indian journal of leprosy
TI - Study of rifampicin resistance and comparison of dapsone resistance of M. leprae in pre- and post-MDT era.
UR - http://www.ijl.org.in/July-Sept%202009_PDF%20Files/4_Abst%20(131-134).pdf
VL - 81
SN - 0254-9395
ER -