TY - JOUR KW - Adult KW - Anti-Infective Agents KW - Autoimmune Diseases KW - Child KW - Dapsone KW - Humans KW - Hypersensitivity KW - Jaundice KW - leprosy KW - Orphan Drug Production KW - Peripheral Nervous System Diseases KW - Pneumocystis carinii KW - Pneumonia, Pneumocystis KW - Skin Diseases KW - Therapies, Investigational KW - Toxoplasmosis AU - Wozel G AB -

After synthesis of dapsone (4,4' diaminodiphenylsulfone) in 1908, the compound was known exclusively in chemistry. Following the epoch-making discovery of the antimicrobial potential for sulfonamides emerged, the sulfone class was included in the medical armamentarium. The therapeutic role of sulfones related to both pathogen-caused diseases and chronic inflammatory dermatoses has led to extensive use in dermatology. At present dapsone is the only sulfone congener available for clinical practice. The sulfone is used in rifampin-based multiple-drug regiments to treat multibacillary and paucibacillary leprosy and to treat Pneumocystis jiroveci pneumonia and prevent toxoplasmosis in individuals with AIDS. In dermatology, dapsone is the preferred drug for treating dermatitis herpetiformis (Duhring's disease) and is useful in the management of a broad range of chronic inflammatory entities, especially autoimmune bullous disorders. With proper administration and monitoring, the sulfone should be considered a useful and safe agent.

BT - Dermatologic clinics C1 - http://www.ncbi.nlm.nih.gov/pubmed/20510768?dopt=Abstract DA - 2010 Jul DO - 10.1016/j.det.2010.03.014 IS - 3 J2 - Dermatol Clin LA - eng N2 -

After synthesis of dapsone (4,4' diaminodiphenylsulfone) in 1908, the compound was known exclusively in chemistry. Following the epoch-making discovery of the antimicrobial potential for sulfonamides emerged, the sulfone class was included in the medical armamentarium. The therapeutic role of sulfones related to both pathogen-caused diseases and chronic inflammatory dermatoses has led to extensive use in dermatology. At present dapsone is the only sulfone congener available for clinical practice. The sulfone is used in rifampin-based multiple-drug regiments to treat multibacillary and paucibacillary leprosy and to treat Pneumocystis jiroveci pneumonia and prevent toxoplasmosis in individuals with AIDS. In dermatology, dapsone is the preferred drug for treating dermatitis herpetiformis (Duhring's disease) and is useful in the management of a broad range of chronic inflammatory entities, especially autoimmune bullous disorders. With proper administration and monitoring, the sulfone should be considered a useful and safe agent.

PY - 2010 SP - 599 EP - 610 T2 - Dermatologic clinics TI - Innovative use of dapsone. VL - 28 SN - 1558-0520 ER -