Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases.
BT - Current opinion in immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/20060279?dopt=Abstract DA - 2010 Feb DO - 10.1016/j.coi.2009.12.001 IS - 1 J2 - Curr. Opin. Immunol. LA - eng N2 -Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases.
PY - 2010 SP - 48 EP - 54 T2 - Current opinion in immunology TI - The innate immune response in leprosy. UR - https://www.frontiersin.org/articles/10.3389/fimmu.2018.00518/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE VL - 22 SN - 1879-0372 ER -