TY - JOUR
KW - Adult
KW - Agranulocytosis
KW - Anemia, Hemolytic
KW - Clofazimine
KW - Dapsone
KW - Drug Therapy, Combination
KW - Female
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Rifampin
AU - Silva IM
AU - Oliveira C
AU - Guedes W
AU - Oliveira BB
AU - Oliveira DAP
AU - Guedes Filho G
AB - <p>Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient who presented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined the importance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects,with a view to improving adhesion to treatment and contributing to the eradication of Hansen's disease as a public health issue.</p>
BT - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/20140364?dopt=Abstract
DA - 2009 Apr
DO - 10.1590/s1413-86702009000200018
IS - 2
J2 - Braz J Infect Dis
LA - eng
N2 - <p>Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient who presented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined the importance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects,with a view to improving adhesion to treatment and contributing to the eradication of Hansen's disease as a public health issue.</p>
PY - 2009
SP - 158
EP - 60
T2 - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
TI - Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report.
VL - 13
SN - 1678-4391
ER -