TY - JOUR
KW - Coccidioidomycosis
KW - Dapsone
KW - Drug Administration Schedule
KW - Erythema Nodosum
KW - Humans
KW - Infarction
KW - leprosy
KW - Mycobacterium leprae
KW - Peptidyl-Dipeptidase A
KW - Prednisone
KW - Skin
KW - Sulfones
AU - Lieberman J
AU - Rea T H
AB - <p>Serum angiotensin-converting enzyme levels were found to be elevated in 71.4% of 42 leprosy patients, both treated and untreated, but in only one of 13 patients with disseminated coccidioidomycosis. The elevations with leprosy were present in association with each of the three major categories: lepromatous, borderline, or tuberculoid. Sulfone therapy had no immediate effect on the elevated serum levels, although long-term sulfone therapy appeared to result in lowering of the level. Corticosteroid therapy had a more immediate and dramatic effect on reducing the elevated angiotensin-converting enzyme level in leprosy. This assay cannot distinguish between sarcoidosis and leprosy or between the various categories of leprosy, but it can help differentiate sarcoidosis from fungal or tuberculous disease. Elevated levels of serum angiotensin-converting enzyme have now been associated with three diseases states: sarcoidosis, Gaucher's disease, and leprosy.</p>
BT - Annals of internal medicine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/199098?dopt=Abstract
DA - 1977 Oct
DO - 10.7326/0003-4819-87-4-422
IS - 4
J2 - Ann. Intern. Med.
LA - eng
N2 - <p>Serum angiotensin-converting enzyme levels were found to be elevated in 71.4% of 42 leprosy patients, both treated and untreated, but in only one of 13 patients with disseminated coccidioidomycosis. The elevations with leprosy were present in association with each of the three major categories: lepromatous, borderline, or tuberculoid. Sulfone therapy had no immediate effect on the elevated serum levels, although long-term sulfone therapy appeared to result in lowering of the level. Corticosteroid therapy had a more immediate and dramatic effect on reducing the elevated angiotensin-converting enzyme level in leprosy. This assay cannot distinguish between sarcoidosis and leprosy or between the various categories of leprosy, but it can help differentiate sarcoidosis from fungal or tuberculous disease. Elevated levels of serum angiotensin-converting enzyme have now been associated with three diseases states: sarcoidosis, Gaucher's disease, and leprosy.</p>
PY - 1977
SP - 423
EP - 5
T2 - Annals of internal medicine
TI - Serum angiotensin-converting enzyme in leprosy and coccidioidomycosis.
VL - 87
SN - 0003-4819
ER -