TY - JOUR
KW - Case-Control Studies
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Humans
KW - Interleukin 1 Receptor Antagonist Protein
KW - Interleukin-1beta
KW - leprosy
KW - Longitudinal studies
KW - Male
KW - Middle Aged
KW - ROC Curve
AU - Costa RD
AU - Mendonça VA
AU - Lyon S
AU - Penido RA
AU - Costa AMDD
AU - Costa MD
AU - Nishi MP
AU - Teixeira MM
AU - Teixeira AL
AU - Antunes CMF
AB - <p>Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1beta and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1beta. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.</p>
BT - Revista da Sociedade Brasileira de Medicina Tropical
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19618085?dopt=Abstract
DA - 2008
DO - 10.1590/s0037-86822008000700020
J2 - Rev. Soc. Bras. Med. Trop.
LA - eng
N2 - <p>Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1beta and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1beta. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.</p>
PY - 2008
SP - 99
EP - 103
T2 - Revista da Sociedade Brasileira de Medicina Tropical
TI - Evaluation of the expression of interleukin 1 beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients.
VL - 41 Suppl 2
SN - 1678-9849
ER -