An 11-year-old black Haitian boy presented with borderline lepromatous leprosy and was treated with rifampicin, dapsone, and clofazimine. After 4 months he developed a severe type 1 reversal reaction without nerve involvement. He was started on prednisolone (1 mg/kg daily). After 4 weeks of treatment with corticosteroids, his condition did not improve and the lesions remained painful. The patient was given a therapeutic trial with twice daily application of topical tacrolimus 0.1% ointment. The result was a dramatic improvement in the skin lesions. The patient's condition was maintained by topical tacrolimus therapy, with healing of all skin lesions. The prednisolone dose was then tapered to zero over a period of 12 weeks. To the best of our knowledge, this is the first report of the efficacy of topical tacrolimus in the treatment of type 1 leprosy reaction.
BT - Indian journal of medical sciences C1 - http://www.ncbi.nlm.nih.gov/pubmed/19770527?dopt=Abstract DA - 2009 Aug DO - 10.4103/0019-5359.55888 IS - 8 J2 - Indian J Med Sci LA - eng N2 -An 11-year-old black Haitian boy presented with borderline lepromatous leprosy and was treated with rifampicin, dapsone, and clofazimine. After 4 months he developed a severe type 1 reversal reaction without nerve involvement. He was started on prednisolone (1 mg/kg daily). After 4 weeks of treatment with corticosteroids, his condition did not improve and the lesions remained painful. The patient was given a therapeutic trial with twice daily application of topical tacrolimus 0.1% ointment. The result was a dramatic improvement in the skin lesions. The patient's condition was maintained by topical tacrolimus therapy, with healing of all skin lesions. The prednisolone dose was then tapered to zero over a period of 12 weeks. To the best of our knowledge, this is the first report of the efficacy of topical tacrolimus in the treatment of type 1 leprosy reaction.
PY - 2009 SP - 359 EP - 62 T2 - Indian journal of medical sciences TI - Type 1 leprosy reversal reaction treated with topical tacrolimus along with systemic corticosteroids. UR - http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2009;volume=63;issue=8;spage=359;epage=362;aulast=Safa VL - 63 SN - 1998-3654 ER -