Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.
BT - The Journal of infectious diseases C1 - http://www.ncbi.nlm.nih.gov/pubmed/19434912?dopt=Abstract DA - 2009 Mar 15 DO - 10.1086/597070 IS - 6 J2 - J. Infect. Dis. LA - eng N2 -Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.
PY - 2009 SP - 801 EP - 4 T2 - The Journal of infectious diseases TI - Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. VL - 199 SN - 0022-1899 ER -