TY - JOUR
KW - Adult
KW - Antigens, CD1
KW - Dendritic Cells
KW - Factor XIIIa
KW - Female
KW - Humans
KW - Immunohistochemistry
KW - leprosy
KW - Male
AU - Quaresma JAS
AU - Oliveira MFA
AU - Ribeiro Guimarães AC
AU - Brito EB
AU - Brito RB
AU - Pagliari C
AU - Brito AC
AU - Xavier MB
AU - Duarte MIS
AB - <p>Leprosy is a curable chronic granulomatous infectious disease caused by the bacillus Mycobacterium leprae. This organism has a high affinity for skin and peripheral nerve cells. In the evolution of infections, the immune status of patients determines the disease expression. Dendritic cells are antigen-presenting cells that phagocytose particles and microorganisms. In skin, dendritic cells are represented by epidermal Langerhans cells and dermal dendrocytes, which can be identified by expression of CD1a and factor XIIIa (FXIIIa). In the present study, 29 skin samples from patients with tuberculoid (13 biopsies) and lepromatous (16 biopsies) leprosy were analyzed by immunohistochemistry using antibodies to CD1a and FXIIIa. Quantitative analysis of labeling pattern showed a clear predominance of dendritic cells in tuberculoid leprosy. Difference between the number of positive cells of immunohistochemistry for the CD1a and FXIIIa staining observed in this study indicates a role for dendritic cells in the cutaneous response to leprosy. Dendritic cells may be a determinant of the course and clinical expression of the disease.</p>
BT - The American Journal of dermatopathology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19590423?dopt=Abstract
DA - 2009 Aug
DO - 10.1097/DAD.0b013e31819f1997
IS - 6
J2 - Am J Dermatopathol
LA - eng
N2 - <p>Leprosy is a curable chronic granulomatous infectious disease caused by the bacillus Mycobacterium leprae. This organism has a high affinity for skin and peripheral nerve cells. In the evolution of infections, the immune status of patients determines the disease expression. Dendritic cells are antigen-presenting cells that phagocytose particles and microorganisms. In skin, dendritic cells are represented by epidermal Langerhans cells and dermal dendrocytes, which can be identified by expression of CD1a and factor XIIIa (FXIIIa). In the present study, 29 skin samples from patients with tuberculoid (13 biopsies) and lepromatous (16 biopsies) leprosy were analyzed by immunohistochemistry using antibodies to CD1a and FXIIIa. Quantitative analysis of labeling pattern showed a clear predominance of dendritic cells in tuberculoid leprosy. Difference between the number of positive cells of immunohistochemistry for the CD1a and FXIIIa staining observed in this study indicates a role for dendritic cells in the cutaneous response to leprosy. Dendritic cells may be a determinant of the course and clinical expression of the disease.</p>
PY - 2009
SP - 527
EP - 31
T2 - The American Journal of dermatopathology
TI - CD1a and factor XIIIa immunohistochemistry in leprosy: a possible role of dendritic cells in the pathogenesis of Mycobacterium leprae infection.
VL - 31
SN - 1533-0311
ER -