The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.
BT - Antimicrobial agents and chemotherapy C1 - http://www.ncbi.nlm.nih.gov/pubmed/19596891?dopt=Abstract DA - 2009 Sep DO - 10.1128/AAC.00722-09 IS - 9 J2 - Antimicrob. Agents Chemother. LA - eng N2 -The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.
PY - 2009 SP - 3989 EP - 91 T2 - Antimicrobial agents and chemotherapy TI - The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently. VL - 53 SN - 1098-6596 ER -