TY - JOUR
KW - Animals
KW - Dose-Response Relationship, Drug
KW - Drug Evaluation, Preclinical
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Mice
KW - Mice, Inbred CBA
KW - Microbial Viability
KW - Mycobacterium leprae
KW - Thiocarbamates
KW - Treatment Outcome
AU - Urlyapova N G
AU - Yuschenko A A
AU - Daudova A D
AU - Makarov V A
AB - <p>Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.</p>
BT - Bulletin of experimental biology and medicine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19110590?dopt=Abstract
DA - 2008 Apr
DO - 10.1007/s10517-008-0114-6
IS - 4
J2 - Bull. Exp. Biol. Med.
LA - eng
N2 - <p>Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.</p>
PY - 2008
SP - 446
EP - 8
T2 - Bulletin of experimental biology and medicine
TI - Antileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives.
VL - 145
SN - 0007-4888
ER -