TY - JOUR
KW - Administration, Oral
KW - Animals
KW - Anti-Bacterial Agents
KW - Colony Count, Microbial
KW - Drug Resistance, Bacterial
KW - Female
KW - Fluoroquinolones
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Nude
KW - Mycobacterium leprae
KW - Structure-Activity Relationship
AU - Gidoh M
AB - <p>Due to the emergence of drug resistant M. leprae, there is a need to look for new drugs for the treatment of leprosy. We evaluated the effectiveness of new quinolones in vitro as well as in vivo. The in vitro and in vivo results suggested that a cyclopropyl group at the 1-position, COOH at the 3-position, OH at the 4-position, NH2 or OH-substitutions at the 5-position, F at the 6-position, 5- and 6-membered rings at the 7-position, halogen (F or Cl) or OCH3 at the 8-position of the quinolone core structure remarkably enhance anti-M. leprae activities of the drug.</p>
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19227145?dopt=Abstract
DA - 2009 Feb
IS - 1
J2 - Nihon Hansenbyo Gakkai Zasshi
LA - jpn
N2 - <p>Due to the emergence of drug resistant M. leprae, there is a need to look for new drugs for the treatment of leprosy. We evaluated the effectiveness of new quinolones in vitro as well as in vivo. The in vitro and in vivo results suggested that a cyclopropyl group at the 1-position, COOH at the 3-position, OH at the 4-position, NH2 or OH-substitutions at the 5-position, F at the 6-position, 5- and 6-membered rings at the 7-position, halogen (F or Cl) or OCH3 at the 8-position of the quinolone core structure remarkably enhance anti-M. leprae activities of the drug.</p>
PY - 2009
SP - 17
EP - 23
T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
TI - [Structure and anti-M. leprae activity relationships of new quinolones].
VL - 78
SN - 1342-3681
ER -