TY - JOUR
KW - Animals
KW - Antibodies, Bacterial
KW - Antigens, Bacterial
KW - Cross-Sectional Studies
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Glycolipids
KW - leprosy
KW - Lipopolysaccharides
KW - Longitudinal studies
KW - Male
KW - Mycobacterium leprae
KW - Pan troglodytes
AU - Gormus B J
AU - Xu K Y
AU - Alford P L
AU - Lee D R
AU - Hubbard G B
AU - Eichberg J W
AU - Meyers W M
AB - <p>Data from longitudinally obtained serum samples spanning several years has permitted us to identify two chimpanzees with leprosy and to estimate the time of Mycobacterium leprae exposure/infection. The results confirm high levels of specific anti-M. leprae phenolic glycolipid-I (PGL-I) as well as anti-lipo-arabinomannan (anti-LAM) antibodies in both chimpanzees, and identify additional chimpanzees with possible M. leprae exposure. The observations are consistent with the hypothesis that leprosy exists in chimpanzees in the U.S.A. and suggest the possibility that M. leprae may be transmitted among chimpanzees. The data suggest that monitoring anti-PGL-I and anti-LAM IgG and IgM levels longitudinally in leprosy contacts may be useful in the recognition of preclinical leprosy.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1890369?dopt=Abstract
DA - 1991 Sep
IS - 3
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>Data from longitudinally obtained serum samples spanning several years has permitted us to identify two chimpanzees with leprosy and to estimate the time of Mycobacterium leprae exposure/infection. The results confirm high levels of specific anti-M. leprae phenolic glycolipid-I (PGL-I) as well as anti-lipo-arabinomannan (anti-LAM) antibodies in both chimpanzees, and identify additional chimpanzees with possible M. leprae exposure. The observations are consistent with the hypothesis that leprosy exists in chimpanzees in the U.S.A. and suggest the possibility that M. leprae may be transmitted among chimpanzees. The data suggest that monitoring anti-PGL-I and anti-LAM IgG and IgM levels longitudinally in leprosy contacts may be useful in the recognition of preclinical leprosy.</p>
PY - 1991
SP - 450
EP - 7
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - A serologic study of naturally acquired leprosy in chimpanzees.
UR - http://ila.ilsl.br/pdfs/v59n3a09.pdf
VL - 59
SN - 0148-916X
ER -