Immunity to intracellular bacteria including Mycobacterium tuberculosis crucially depends on intricate interactions between T lymphocytes and macrophages. Before contact with T lymphocytes macrophages serve as habitat for M. tuberculosis organisms; after activation by T cells they become major effectors against these pathogens. T cells comprise different subsets which express different functional activities. This paper describes evidence that different T cell subsets (CD4 alpha/beta T cells, CD8 alpha/beta T cells and gamma/delta T cells) as well as different T cell functions (interleukin secretion and target cell lysis) contribute to immunity against tuberculosis.
BT - Pathobiology : journal of immunopathology, molecular and cellular biology C1 - http://www.ncbi.nlm.nih.gov/pubmed/1883509?dopt=Abstract DA - 1991 DO - 10.1159/000163634 IS - 3 J2 - Pathobiology LA - eng N2 -Immunity to intracellular bacteria including Mycobacterium tuberculosis crucially depends on intricate interactions between T lymphocytes and macrophages. Before contact with T lymphocytes macrophages serve as habitat for M. tuberculosis organisms; after activation by T cells they become major effectors against these pathogens. T cells comprise different subsets which express different functional activities. This paper describes evidence that different T cell subsets (CD4 alpha/beta T cells, CD8 alpha/beta T cells and gamma/delta T cells) as well as different T cell functions (interleukin secretion and target cell lysis) contribute to immunity against tuberculosis.
PY - 1991 SP - 153 EP - 5 T2 - Pathobiology : journal of immunopathology, molecular and cellular biology TI - The macrophage in tuberculosis: sinner or saint? The T cell decides. VL - 59 SN - 1015-2008 ER -