TY - JOUR
KW - Antibodies, Bacterial
KW - Antigens, Bacterial
KW - Carbohydrate Sequence
KW - Clofazimine
KW - Dapsone
KW - Drug Therapy, Combination
KW - Glycolipids
KW - Humans
KW - Immunoglobulin M
KW - Leprostatic Agents
KW - leprosy
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Molecular Sequence Data
KW - Mycobacterium leprae
KW - Rifampin
KW - Skin
KW - Time Factors
AU - Roche P W
AU - Britton W J
AU - Neupane K D
AU - Failbus S S
AU - Cho S N
AU - Theuvenet W J
AB - <p>We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.</p>
BT - The American journal of tropical medicine and hygiene
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1858971?dopt=Abstract
DA - 1991 Jun
DO - 10.4269/ajtmh.1991.44.702
IS - 6
J2 - Am. J. Trop. Med. Hyg.
LA - eng
N2 - <p>We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.</p>
PY - 1991
SP - 702
EP - 8
T2 - The American journal of tropical medicine and hygiene
TI - The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.
VL - 44
SN - 0002-9637
ER -