TY - JOUR KW - Adolescent KW - Adult KW - Aged KW - Antigens, Bacterial KW - Dose-Response Relationship, Immunologic KW - Female KW - Heat-Shock Proteins KW - Humans KW - Immunity, Cellular KW - leprosy KW - Lymphocyte Activation KW - Male KW - Middle Aged KW - Mycobacterium leprae KW - Nepal KW - T-Lymphocytes AU - Roche P W AU - Theuvenet W J AU - Britton W J AB -

Sixty-three leprosy patients, representing the entire leprosy spectrum from tuberculoid to lepromatous disease, and 17 healthy Nepali subjects were tested for their T-cell responses to the purified p65 and p70 protein antigens of Mycobacterium bovis BCG using a lymphocyte proliferative assay. There was strong correlation between the responses to BCG and M. leprae and the responses to the two antigens. Patients and controls lacking a response to either of the whole cell preparations failed to respond to the purified antigens, while BCG responders at the lepromatous pole of the disease did mount a response to both antigens. Significant differences in the magnitude of the responses to these antigens were obtained between controls and the disease groups. In individual subjects, responses to the two antigens were significantly correlated to each other.

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 - http://www.ncbi.nlm.nih.gov/pubmed/1602192?dopt=Abstract DA - 1992 Mar IS - 1 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -

Sixty-three leprosy patients, representing the entire leprosy spectrum from tuberculoid to lepromatous disease, and 17 healthy Nepali subjects were tested for their T-cell responses to the purified p65 and p70 protein antigens of Mycobacterium bovis BCG using a lymphocyte proliferative assay. There was strong correlation between the responses to BCG and M. leprae and the responses to the two antigens. Patients and controls lacking a response to either of the whole cell preparations failed to respond to the purified antigens, while BCG responders at the lepromatous pole of the disease did mount a response to both antigens. Significant differences in the magnitude of the responses to these antigens were obtained between controls and the disease groups. In individual subjects, responses to the two antigens were significantly correlated to each other.

PY - 1992 SP - 36 EP - 43 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Cellular immune responses to mycobacterial heat shock proteins in Nepali leprosy patients and controls. UR - http://ila.ilsl.br/pdfs/v60n1a06.pdf VL - 60 SN - 0148-916X ER -