TY - JOUR
KW - Adult
KW - Anti-Bacterial Agents
KW - Erythema Nodosum
KW - Eye Infections, Bacterial
KW - Follow-Up Studies
KW - Humans
KW - Leprosy, lepromatous
KW - Male
KW - Rupture, Spontaneous
KW - Sclera
KW - Scleral Diseases
KW - Severity of Illness Index
AU - Rathinam S R
AU - Khazaei H
AU - Job C K
AB - <p>Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae , clinically present either as tuberculoid, borderline or lepromatous type. Erythema nodosum leprosum (ENL) is an acute humoral response in the chronic course of lepromatous leprosy. Although very severe ENL reactions are known in systemic leprosy, such severity is rare in ocular tissues. A leprosy uveitis patient suffered from a severe form of post-therapeutic ENL reaction which resulted in perforation of the globe at the site of preexisting subconjunctival leproma. Painful blind eye was enucleated. Histopathological study revealed infiltration of numerous polymorphs and macrophages packed with acid-fast bacilli in the conjunctiva, cornea, ciliary body, ora serrata and sclera. A profuse influx of neutrophils on a background of macrophages packed with M. leprae confirmed the ocular ENL reaction. This case is reported to alert the ophthalmologists to a rare ocular complication of ENL.</p>
BT - Indian journal of ophthalmology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/18711273?dopt=Abstract
DA - 2008 Sep-Oct
DO - 10.4103/0301-4738.42421
IS - 5
J2 - Indian J Ophthalmol
LA - eng
N2 - <p>Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae , clinically present either as tuberculoid, borderline or lepromatous type. Erythema nodosum leprosum (ENL) is an acute humoral response in the chronic course of lepromatous leprosy. Although very severe ENL reactions are known in systemic leprosy, such severity is rare in ocular tissues. A leprosy uveitis patient suffered from a severe form of post-therapeutic ENL reaction which resulted in perforation of the globe at the site of preexisting subconjunctival leproma. Painful blind eye was enucleated. Histopathological study revealed infiltration of numerous polymorphs and macrophages packed with acid-fast bacilli in the conjunctiva, cornea, ciliary body, ora serrata and sclera. A profuse influx of neutrophils on a background of macrophages packed with M. leprae confirmed the ocular ENL reaction. This case is reported to alert the ophthalmologists to a rare ocular complication of ENL.</p>
PY - 2008
SP - 417
EP - 9
T2 - Indian journal of ophthalmology
TI - Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: a case report.
VL - 56
SN - 0301-4738
ER -