TY - JOUR
KW - Animals
KW - B-Lymphocytes
KW - Disease Models, Animal
KW - Disease Susceptibility
KW - leprosy
KW - Mice
KW - Mice, SCID
KW - Mycobacterium leprae
KW - Severe Combined Immunodeficiency
KW - T-Lymphocytes
AU - Yogi Y
AU - NAKAMURA K
AU - Inoue T
AU - Kawatsu K
AU - Kashiwabara Y
AU - Sakamoto Y
AU - Izumi S
AU - Saito M
AU - Hioki K
AU - Nomura T
AB - <p>Inoculation of M. leprae were made into the both hind feet at a dose of 4.8 x 10(6) bacilli per foot in order to determine the susceptibility to M. leprae of SCID mice which is severely deficient in both T- and B cell immunity. SCID mice was found to have an extremely high susceptibility to M. leprae, and the progress of infection observed in the SCID mice were shown a rapid systemic spread of infection at the all over the tissues as well as the growth of the leprosy bacilli at the site of inoculation. Therefore, SCID mice can be used as a suitable multibacillary model for the study of leprosy.</p>
BT - Nihon Rai Gakkai zasshi
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1843227?dopt=Abstract
DA - 1991 Jul-Dec
DO - 10.5025/hansen1977.60.139
IS - 3-4
J2 - Nihon Rai Gakkai Zasshi
LA - eng
N2 - <p>Inoculation of M. leprae were made into the both hind feet at a dose of 4.8 x 10(6) bacilli per foot in order to determine the susceptibility to M. leprae of SCID mice which is severely deficient in both T- and B cell immunity. SCID mice was found to have an extremely high susceptibility to M. leprae, and the progress of infection observed in the SCID mice were shown a rapid systemic spread of infection at the all over the tissues as well as the growth of the leprosy bacilli at the site of inoculation. Therefore, SCID mice can be used as a suitable multibacillary model for the study of leprosy.</p>
PY - 1991
SP - 139
EP - 45
T2 - Nihon Rai Gakkai zasshi
TI - Susceptibility of severe combined immunodeficient (SCID) mice to Mycobacterium leprae: multiplication of the bacillus and dissemination of the infection at early stage.
VL - 60
SN - 0386-3980
ER -