TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Animals
KW - Antigens, CD1
KW - Antigens, CD1d
KW - Female
KW - Flow Cytometry
KW - Galactosylceramides
KW - Humans
KW - Immunophenotyping
KW - Killer Cells, Natural
KW - leprosy
KW - Mice
KW - Mice, Inbred C57BL
KW - Middle Aged
KW - Mycobacterium leprae
KW - Mycobacterium tuberculosis
KW - Statistics, Nonparametric
KW - T-Lymphocyte Subsets
KW - Tuberculosis
AU - Im JS
AU - Kang T
AU - Lee S
AU - Kim C
AU - Lee S
AU - Venkataswamy MM
AU - Serfass E
AU - Chen B
AU - Illarionov PA
AU - Besra G
AU - Jacobs W
AU - Chae G
AU - Porcelli SA
AB - <p>CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.</p>
BT - Clinical immunology (Orlando, Fla.)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/18308638?dopt=Abstract
DA - 2008 May
DO - 10.1016/j.clim.2007.12.005
IS - 2
J2 - Clin. Immunol.
LA - eng
N2 - <p>CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.</p>
PY - 2008
SP - 214
EP - 24
T2 - Clinical immunology (Orlando, Fla.)
TI - Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.
VL - 127
SN - 1521-7035
ER -