A study was undertaken to find out the usefulness of determining the circulating levels of beta-glucuronidase, a lysosomal enzyme in leprosy affected children of less than 15 years of age. The serum enzyme levels were significantly higher in BB/BL patients compared to healthy control children as well as children with skin diseases other than leprosy. Treatment with Multidrug regimen advocated by WHO for multi/paucibacillary leprosy resulted in a significant fall in the serum enzyme levels in BB and BL cases. The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/18035775?dopt=Abstract CN - NANDAN 2007 DA - 2007 Sep IS - 3 J2 - Lepr Rev LA - eng N2 -A study was undertaken to find out the usefulness of determining the circulating levels of beta-glucuronidase, a lysosomal enzyme in leprosy affected children of less than 15 years of age. The serum enzyme levels were significantly higher in BB/BL patients compared to healthy control children as well as children with skin diseases other than leprosy. Treatment with Multidrug regimen advocated by WHO for multi/paucibacillary leprosy resulted in a significant fall in the serum enzyme levels in BB and BL cases. The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.
PY - 2007 SP - 243 EP - 7 T2 - Leprosy review TI - Serum beta-glucuronidase levels in children with leprosy. UR - https://leprosyreview.org/article/78/3/24-3247 VL - 78 SN - 0305-7518 ER -