TY - JOUR
KW - Angiogenesis Inhibitors
KW - Blood Vessels
KW - Humans
KW - Immunohistochemistry
KW - leprosy
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Microcirculation
KW - Neovascularization, Pathologic
KW - Platelet Endothelial Cell Adhesion Molecule-1
KW - Skin
AU - Bhandarkar SS
AU - Cohen C
AU - Kuruvila M
AU - Rea T
AU - Mackelfresh JB
AU - Lee DJ
AU - Modlin RL
AU - Arbiser J
AB - <p><b>OBJECTIVE: </b>To examine the potential role of angiogenesis in leprosy.</p><p><b>DESIGN: </b>Immunohistochemical analysis of leprosy lesions.</p><p><b>SETTING: </b>Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.</p><p><b>PATIENTS: </b>Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.</p><p><b>MAIN OUTCOME MEASURE: </b>CD31 microvessel counts.</p><p><b>RESULTS: </b>The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.</p><p><b>CONCLUSIONS: </b>Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.</p>
BT - Archives of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/18087002?dopt=Abstract
DA - 2007 Dec
DO - 10.1001/archderm.143.12.1527
IS - 12
J2 - Arch Dermatol
LA - eng
N2 - <p><b>OBJECTIVE: </b>To examine the potential role of angiogenesis in leprosy.</p><p><b>DESIGN: </b>Immunohistochemical analysis of leprosy lesions.</p><p><b>SETTING: </b>Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.</p><p><b>PATIENTS: </b>Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.</p><p><b>MAIN OUTCOME MEASURE: </b>CD31 microvessel counts.</p><p><b>RESULTS: </b>The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.</p><p><b>CONCLUSIONS: </b>Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.</p>
PY - 2007
SP - 1527
EP - 9
T2 - Archives of dermatology
TI - Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
VL - 143
SN - 1538-3652
ER -