TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Clofazimine
KW - Dapsone
KW - Drug Therapy, Combination
KW - Female
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Nepal
KW - Retrospective Studies
KW - Rifampin
KW - Treatment Outcome
AU - Sapkota BR
AU - Shrestha K
AU - Pandey B
AU - Walker SL
AB - <p><b>INTRODUCTION: </b>Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal. DHS and other adverse effects of dapsone lead to withdrawal of the drug.</p><p><b>METHODS: </b>We reviewed the notes of patients who had dapsone withdrawn from their multi-drug therapy (MDT) following an adverse reaction to the drug between 1990 and 2007.</p><p><b>RESULTS: </b>105 patients were identified from the database and 67 had a documented completion of a modified course of MDT. The majority were treated with rifampicin and clofazimine. All 36 individuals who were slit-skin smear positive had a satisfactory fall in their mean bacterial index. There were no cases of relapse.</p><p><b>CONCLUSIONS: </b>Rifampicin and clofazimine appear to be satisfactory treatment for both paucibacillary and multibacillary patients who have to have dapsone stopped because of severe adverse effects.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19274989?dopt=Abstract
CN - Infolep Library - available
DA - 2008 Dec
IS - 4
J2 - Lepr Rev
LA - eng
N2 - <p><b>INTRODUCTION: </b>Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal. DHS and other adverse effects of dapsone lead to withdrawal of the drug.</p><p><b>METHODS: </b>We reviewed the notes of patients who had dapsone withdrawn from their multi-drug therapy (MDT) following an adverse reaction to the drug between 1990 and 2007.</p><p><b>RESULTS: </b>105 patients were identified from the database and 67 had a documented completion of a modified course of MDT. The majority were treated with rifampicin and clofazimine. All 36 individuals who were slit-skin smear positive had a satisfactory fall in their mean bacterial index. There were no cases of relapse.</p><p><b>CONCLUSIONS: </b>Rifampicin and clofazimine appear to be satisfactory treatment for both paucibacillary and multibacillary patients who have to have dapsone stopped because of severe adverse effects.</p>
PY - 2008
SP - 425
EP - 8
T2 - Leprosy review
TI - A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone.
UR - https://leprosyreview.org/article/79/4/42-5428
VL - 79
SN - 0305-7518
ER -