TY - JOUR
KW - Bone Marrow
KW - Histocytochemistry
KW - Humans
KW - leprosy
KW - Lipid Metabolism
KW - Macrophages
AU - Sen R
AU - Sehgal P K
AU - Dixit V
AU - Singh U
AU - Chaudhary S D
AU - Sikka R
AU - Jain V K
AB - <p>While conducting a study to observe bone marrow cytomorphological changes in multibacillary leprosy, lipid laden macrophages as seen in sphingolipidoses were noted. The present study was planned to observe the occurrence and morphological characterization of these macrophages in various types of leprosy. Bone marrow records from 48 cases of paucibacillary and 72 cases of multibacillary leprosy were analysed. The macrophages accounting at the most for 3.5% of marrow cells were observed in 5 cases of paucibacillary and 43 cases of multibacillary leprosy with a maximum incidence being observed in patients with ENL (16/17). The lipid present in the cytoplasm of these cells could be derived from the lipid of the cell wall of Mycobacterium leprae. To the best of our knowledge, these cells have not been reported in leprosy so far.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1784152?dopt=Abstract
CN - Infolep Library - available
DA - 1991 Dec
DO - 10.5935/0305-7518.19910043
IS - 4
J2 - Lepr Rev
LA - eng
N2 - <p>While conducting a study to observe bone marrow cytomorphological changes in multibacillary leprosy, lipid laden macrophages as seen in sphingolipidoses were noted. The present study was planned to observe the occurrence and morphological characterization of these macrophages in various types of leprosy. Bone marrow records from 48 cases of paucibacillary and 72 cases of multibacillary leprosy were analysed. The macrophages accounting at the most for 3.5% of marrow cells were observed in 5 cases of paucibacillary and 43 cases of multibacillary leprosy with a maximum incidence being observed in patients with ENL (16/17). The lipid present in the cytoplasm of these cells could be derived from the lipid of the cell wall of Mycobacterium leprae. To the best of our knowledge, these cells have not been reported in leprosy so far.</p>
PY - 1991
SP - 374
EP - 80
T2 - Leprosy review
TI - Lipid-laden macrophages in bone marrow of leprosy patients.
UR - http://leprev.ilsl.br/pdfs/1991/v62n4/pdf/v62n4a03.pdf
VL - 62
SN - 0305-7518
ER -