TY - JOUR
KW - Aged
KW - Anti-Bacterial Agents
KW - Clofazimine
KW - Cystamine
KW - Drug Therapy, Combination
KW - Follow-Up Studies
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Minocycline
KW - Ofloxacin
KW - Rifampin
KW - Time Factors
KW - Treatment Outcome
AU - Ozaki M
AU - Ishikawa M
AB - <p>This reports a long-term follow-up study on clinical effects of ofloxacin (OFLX)-combined therapy to 14 leprosy patients with various types and stages. Combined drugs were diaminodiphenyl sulfone (DDS), rifampicin (RFP) and clofazimine. Clinical evaluation of the treatment after OFLX-combined therapy was remarkable improvement 10 cases, improvement 3 and re-exacerbated after improvement 1 to whom clofazimine and minocycline were prescribed. The evaluation during the follow-up was remarkable improvement 10, improvement 1; three cases died of traffic accident or complications not related to chemotherapy and none of them showed relapse of leprosy. Bacterial negativity after onset of OFLX-combined therapy was achieved in about the same periods as RFP-combined therapy. OFLX-combined therapy was effective and safe. This follow-up study supports the efficacy of clinical guideline for the use of new quinolones published by Japanese leprosy Association.</p>
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/17877033?dopt=Abstract
DA - 2007 Sep
IS - 3
J2 - Nihon Hansenbyo Gakkai Zasshi
LA - jpn
N2 - <p>This reports a long-term follow-up study on clinical effects of ofloxacin (OFLX)-combined therapy to 14 leprosy patients with various types and stages. Combined drugs were diaminodiphenyl sulfone (DDS), rifampicin (RFP) and clofazimine. Clinical evaluation of the treatment after OFLX-combined therapy was remarkable improvement 10 cases, improvement 3 and re-exacerbated after improvement 1 to whom clofazimine and minocycline were prescribed. The evaluation during the follow-up was remarkable improvement 10, improvement 1; three cases died of traffic accident or complications not related to chemotherapy and none of them showed relapse of leprosy. Bacterial negativity after onset of OFLX-combined therapy was achieved in about the same periods as RFP-combined therapy. OFLX-combined therapy was effective and safe. This follow-up study supports the efficacy of clinical guideline for the use of new quinolones published by Japanese leprosy Association.</p>
PY - 2007
SP - 207
EP - 18
T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
TI - [Long-term follow-up of ofloxacin-combined therapy for leprosy patients].
VL - 76
SN - 1342-3681
ER -