TY - JOUR KW - Hemoglobinopathies KW - Hemoglobins, Abnormal KW - Heterozygote KW - Humans KW - leprosy KW - Mozambique KW - Sickle Cell Trait KW - Thalassemia AU - Nowicki L AU - Behnken L AU - Martin H AB -

In 588 bloodsamples of negride natives from Moçambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.

BT - Blut C1 - http://www.ncbi.nlm.nih.gov/pubmed/1191781?dopt=Abstract DA - 1975 Nov DO - 10.1007/bf01634144 IS - 5 J2 - Blut LA - ger N2 -

In 588 bloodsamples of negride natives from Moçambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.

PY - 1975 SP - 283 EP - 90 T2 - Blut TI - [Frequency of hemoglobin abnormalities and hemoglobinopathies in Mozambique peoples (comparison between leprosy and non-leprosy subjects]. TT - Über die Häufigkeit von Hämoglobinanomalien und Hämoglobinopathien bei moçambiquanischen Völkerschaften. (Mit Vergleich zwischen Leprösen und Nicht-Leprösen) VL - 31 SN - 0006-5242 ER -