TY - JOUR
KW - Alleles
KW - Case-Control Studies
KW - Cation Transport Proteins
KW - Disease Susceptibility
KW - genotype
KW - Humans
KW - leprosy
KW - Polymorphism, Genetic
KW - Risk Factors
KW - Thailand
KW - Tumor Necrosis Factor-alpha
AU - Vejbaesya S
AU - Mahaisavariya P
AU - Luangtrakool P
AU - Sermduangprateep C
AB - <p><b>OBJECTIVE: </b>To determine the association of TNF alpha and NRAMP1 polymorphisms in leprosy.</p><p><b>MATERIAL AND METHOD: </b>The polymorphisms of TNF alpha at -238, -308, and NRAMP1 at INT4, D543N, and3' UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms.</p><p><b>RESULTS: </b>The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls.</p><p><b>CONCLUSION: </b>TNF-308A was associated with susceptibility to multibacillary leprosy.</p>
BT - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
C1 - http://www.ncbi.nlm.nih.gov/pubmed/17624216?dopt=Abstract
DA - 2007 Jun
IS - 6
J2 - J Med Assoc Thai
LA - eng
N2 - <p><b>OBJECTIVE: </b>To determine the association of TNF alpha and NRAMP1 polymorphisms in leprosy.</p><p><b>MATERIAL AND METHOD: </b>The polymorphisms of TNF alpha at -238, -308, and NRAMP1 at INT4, D543N, and3' UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms.</p><p><b>RESULTS: </b>The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls.</p><p><b>CONCLUSION: </b>TNF-308A was associated with susceptibility to multibacillary leprosy.</p>
PY - 2007
SP - 1188
EP - 92
T2 - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
TI - TNF alpha and NRAMP1 polymorphisms in leprosy.
VL - 90
SN - 0125-2208
ER -