TY - JOUR
KW - Adult
KW - Anti-HIV Agents
KW - Brazil
KW - Female
KW - HIV Infections
KW - HIV-1
KW - Histocytochemistry
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Pregnancy
KW - Pregnancy Complications, Infectious
KW - Skin
AU - Trindade M A B
AU - Valente N Y S
AU - Manini M I P
AU - Takahashi M D F
AU - Anjos C F D
AU - Benard G
AU - Naafs B
AB - <p>Two case reports of patients with human immunodeficiency virus type 1 (HIV-1) infection who developed leprosy are presented. Both developed type 1 leprosy reactions in the absence of antiretroviral therapy. Reactions have been described for a number of HIV-1- and Mycobacterium leprae-coinfected patients and have been considered to be part of an immune reconstitution inflammatory syndrome (IRIS) since the reactions were usually linked to the administration of highly active antiretroviral therapy. The reports of our two patients suggest that the type 1 reactions in patients with leprosy and HIV may not always be an IRIS manifestation but may be akin to the classical reactional state described for the natural course of leprosy infection, which occurs in leprosy patients due to the fluctuations of the antimycobacterial immune response, whether they are coinfected with HIV or not.</p>
BT - Journal of clinical microbiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/17021066?dopt=Abstract
DA - 2006 Dec
DO - 10.1128/JCM.01425-06
IS - 12
J2 - J. Clin. Microbiol.
LA - eng
N2 - <p>Two case reports of patients with human immunodeficiency virus type 1 (HIV-1) infection who developed leprosy are presented. Both developed type 1 leprosy reactions in the absence of antiretroviral therapy. Reactions have been described for a number of HIV-1- and Mycobacterium leprae-coinfected patients and have been considered to be part of an immune reconstitution inflammatory syndrome (IRIS) since the reactions were usually linked to the administration of highly active antiretroviral therapy. The reports of our two patients suggest that the type 1 reactions in patients with leprosy and HIV may not always be an IRIS manifestation but may be akin to the classical reactional state described for the natural course of leprosy infection, which occurs in leprosy patients due to the fluctuations of the antimycobacterial immune response, whether they are coinfected with HIV or not.</p>
PY - 2006
SP - 4616
EP - 8
T2 - Journal of clinical microbiology
TI - Two patients coinfected with Mycobacterium leprae and human immunodeficiency virus type 1 and naive for antiretroviral therapy who exhibited type 1 leprosy reactions mimicking the immune reconstitution inflammatory syndrome.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698401/pdf/1425-06.pdf
VL - 44
SN - 0095-1137
ER -