TY - JOUR
KW - Animals
KW - Clofazimine
KW - Culture Media
KW - Dapsone
KW - Drug Interactions
KW - Drug Therapy, Combination
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Microbial Sensitivity Tests
KW - Mycobacterium leprae
KW - Rifabutin
KW - Rifampin
KW - Rifamycins
AU - Dhople A M
AU - Lamoureux L C
AU - Gardner G D
AB - <p>Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1664440?dopt=Abstract
CN - Infolep Library - available
DA - 1991 Apr-Jun
IS - 2
J2 - Indian J Lepr
LA - eng
N2 - <p>Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.</p>
PY - 1991
SP - 166
EP - 79
T2 - Indian journal of leprosy
TI - In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
VL - 63
SN - 0254-9395
ER -