TY - JOUR
KW - Adult
KW - Cell Adhesion Molecules
KW - Female
KW - Gene Frequency
KW - Humans
KW - Lectins
KW - Lectins, C-Type
KW - leprosy
KW - Male
KW - Molecular Epidemiology
KW - Mycobacterium leprae
KW - Pakistan
KW - Population
KW - Receptors, Cell Surface
AU - Barreiro LB
AU - Quach H
AU - Krahenbuhl JL
AU - Khaliq S
AU - Mohyuddin A
AU - Mehdi QS
AU - Gicquel B
AU - Neyrolles O
AU - Quintana-Murci L
AB - <p>The C-type lectin DC-SIGN is involved in early interactions between human innate immune cells and a variety of pathogens. Here we sought to evaluate whether DC-SIGN interacts with the leprosy bacillus, Mycobacterium leprae, and whether DC-SIGN genetic variation influences the susceptibility and/or pathogenesis of the disease. A case-control study conducted in a cohort of 272 individuals revealed no association between DC-SIGN variation and leprosy. However, our results clearly show that DC-SIGN recognizes M. leprae, indicating that mycobacteria recognition by this lectin is not as narrowly restricted to the Mycobacterium tuberculosis complex as previously thought. Altogether, our results provide further elucidation of M. leprae interactions with the host innate immune cells and emphasize the importance of DC-SIGN in the early interactions between the human host and the infectious agents.</p>
BT - Human immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/16698431?dopt=Abstract
DA - 2006 Jan-Feb
DO - 10.1016/j.humimm.2006.02.028
IS - 1-2
J2 - Hum. Immunol.
LA - eng
N2 - <p>The C-type lectin DC-SIGN is involved in early interactions between human innate immune cells and a variety of pathogens. Here we sought to evaluate whether DC-SIGN interacts with the leprosy bacillus, Mycobacterium leprae, and whether DC-SIGN genetic variation influences the susceptibility and/or pathogenesis of the disease. A case-control study conducted in a cohort of 272 individuals revealed no association between DC-SIGN variation and leprosy. However, our results clearly show that DC-SIGN recognizes M. leprae, indicating that mycobacteria recognition by this lectin is not as narrowly restricted to the Mycobacterium tuberculosis complex as previously thought. Altogether, our results provide further elucidation of M. leprae interactions with the host innate immune cells and emphasize the importance of DC-SIGN in the early interactions between the human host and the infectious agents.</p>
PY - 2006
SP - 102
EP - 7
T2 - Human immunology
TI - DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.
VL - 67
SN - 0198-8859
ER -