The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6 bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indonesia, and Myanmar. No isolates with four copies of 6 bp were detected from Myanmar, Okinawa, and Japanese Brazilian patients. Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan.
BT - FEMS microbiology letters C1 - http://www.ncbi.nlm.nih.gov/pubmed/16842372?dopt=Abstract DA - 2006 Aug DO - 10.1111/j.1574-6968.2006.00346.x IS - 1 J2 - FEMS Microbiol. Lett. LA - eng N2 -The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6 bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indonesia, and Myanmar. No isolates with four copies of 6 bp were detected from Myanmar, Okinawa, and Japanese Brazilian patients. Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan.
PY - 2006 SP - 150 EP - 4 T2 - FEMS microbiology letters TI - Genotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosy. UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2006.00346.x/pdf VL - 261 SN - 0378-1097 ER -