TY - JOUR
KW - Animals
KW - Anti-Bacterial Agents
KW - Azithromycin
KW - Clarithromycin
KW - Erythromycin
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Mycobacterium leprae
KW - Roxithromycin
AU - Gelber R H
AU - Siu P
AU - Tsang M
AU - Murray L P
AB - <p>We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.</p>
BT - Antimicrobial agents and chemotherapy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1648889?dopt=Abstract
DA - 1991 Apr
DO - 10.1128/aac.35.4.760
IS - 4
J2 - Antimicrob. Agents Chemother.
LA - eng
N2 - <p>We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.</p>
PY - 1991
SP - 760
EP - 3
T2 - Antimicrobial agents and chemotherapy
TI - Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice.
VL - 35
SN - 0066-4804
ER -