TY - JOUR
KW - Adolescent
KW - Adult
KW - Age Factors
KW - BCG Vaccine
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Immunization, Secondary
KW - leprosy
KW - Male
AU - Setia MS
AU - Steinmaus C
AU - Ho C
AU - Rutherford GW
AB - <p>The present meta-analysis investigates the role of BCG-a widely used yet controversial vaccine-in the prevention of leprosy. The electronic databases Medline, Embase, the Cochrane Library, and LILACS were searched to identify studies assessing the protective effect of BCG against leprosy. We included seven experimental studies and 19 observational studies. The experimental studies demonstrated an overall protective effect of 26% (95% CI 14-37%). At 61% (95% CI 51-70%), the observational studies overestimated the protective effect. The age at vaccination did not predict the protective effect of BCG. An additional dose of BCG was more protective in the prevention of leprosy compared with a single dose. An additional dose of BCG may be warranted for contacts of leprosy patients in areas where leprosy continues to be a public-health problem.</p>
BT - The Lancet. Infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/16500597?dopt=Abstract
CN - SETIA 2006
DA - 2006 Mar
DO - 10.1016/S1473-3099(06)70412-1
IS - 3
J2 - Lancet Infect Dis
LA - eng
N2 - <p>The present meta-analysis investigates the role of BCG-a widely used yet controversial vaccine-in the prevention of leprosy. The electronic databases Medline, Embase, the Cochrane Library, and LILACS were searched to identify studies assessing the protective effect of BCG against leprosy. We included seven experimental studies and 19 observational studies. The experimental studies demonstrated an overall protective effect of 26% (95% CI 14-37%). At 61% (95% CI 51-70%), the observational studies overestimated the protective effect. The age at vaccination did not predict the protective effect of BCG. An additional dose of BCG was more protective in the prevention of leprosy compared with a single dose. An additional dose of BCG may be warranted for contacts of leprosy patients in areas where leprosy continues to be a public-health problem.</p>
PY - 2006
SP - 162
EP - 70
T2 - The Lancet. Infectious diseases
TI - The role of BCG in prevention of leprosy: a meta-analysis.
VL - 6
SN - 1473-3099
ER -