Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-control studies with candidate genes and genome-wide screens of affected populations, there is substantial evidence for the role of genetic factors in the susceptibility to mycobacterial disease. These studies have defined immunological processes essential for the control of mycobacteria infections in humans.
BT - Immunology and cell biology C1 - http://www.ncbi.nlm.nih.gov/pubmed/16519730?dopt=Abstract CN - FERNANDO 2006 DA - 2006 Apr DO - 10.1111/j.1440-1711.2006.01420.x IS - 2 J2 - Immunol. Cell Biol. LA - eng N2 -Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-control studies with candidate genes and genome-wide screens of affected populations, there is substantial evidence for the role of genetic factors in the susceptibility to mycobacterial disease. These studies have defined immunological processes essential for the control of mycobacteria infections in humans.
PY - 2006 SP - 125 EP - 37 T2 - Immunology and cell biology TI - Genetic susceptibility to mycobacterial disease in humans. VL - 84 SN - 0818-9641 ER -