TY - JOUR
KW - Antigen-Antibody Complex
KW - Complement C3
KW - Complement System Proteins
KW - Dose-Response Relationship, Drug
KW - Hemolysis
KW - Humans
KW - Leprostatic Agents
KW - Male
KW - Solubility
AU - Kashyap A
AU - Sehgal V N
AU - Sahu A
AU - Saha K
AB - <p>Incubation of pre-formed immune complexes (IC) (125I-HSA--anti-HSA) with normal human serum resulted in solubilization of IC. When various anti-leprosy drugs were added to human sera, solubilization of IC was fairly explicit with clofazimine, whereas this effect was marginal with dapsone. Rifampicin hardly displayed this effect. Aspirin, chloroquine, and prednisolone, the drugs used in addition to multi-drug therapy to control reactions in leprosy, were in a position to inhibit the solubilization of 125I HSA--anti-HSA by normal serum only at a very high dose. From the current data of the inhibition of solubilization of pre-formed IC along with our earlier observations on the modulation of complement-mediated haemolysis by these drugs, it may be possible to postulate that clofazimine as well as chloroquine affect early complement components. This may in turn be responsible for preventing the deposition of C3 complement onto IC.</p>
BT - International journal of immunopharmacology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1624226?dopt=Abstract
DA - 1992 Feb
DO - 10.1016/0192-0561(92)90039-n
IS - 2
J2 - Int. J. Immunopharmacol.
LA - eng
N2 - <p>Incubation of pre-formed immune complexes (IC) (125I-HSA--anti-HSA) with normal human serum resulted in solubilization of IC. When various anti-leprosy drugs were added to human sera, solubilization of IC was fairly explicit with clofazimine, whereas this effect was marginal with dapsone. Rifampicin hardly displayed this effect. Aspirin, chloroquine, and prednisolone, the drugs used in addition to multi-drug therapy to control reactions in leprosy, were in a position to inhibit the solubilization of 125I HSA--anti-HSA by normal serum only at a very high dose. From the current data of the inhibition of solubilization of pre-formed IC along with our earlier observations on the modulation of complement-mediated haemolysis by these drugs, it may be possible to postulate that clofazimine as well as chloroquine affect early complement components. This may in turn be responsible for preventing the deposition of C3 complement onto IC.</p>
PY - 1992
SP - 269
EP - 73
T2 - International journal of immunopharmacology
TI - Anti-leprosy drugs inhibit the complement-mediated solubilization of pre-formed immune complexes in vitro.
VL - 14
SN - 0192-0561
ER -