Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.
BT - Infection and immunity C1 - http://www.ncbi.nlm.nih.gov/pubmed/1639478?dopt=Abstract DA - 1992 Aug IS - 8 J2 - Infect. Immun. LA - eng N2 -Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.
PY - 1992 SP - 3105 EP - 10 T2 - Infection and immunity TI - hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC257288/pdf/iai00032-0089.pdf VL - 60 SN - 0019-9567 ER -