TY - JOUR
KW - Animals
KW - Dapsone
KW - Dihydropteroate Synthase
KW - Dose-Response Relationship, Drug
KW - Drug Resistance, Bacterial
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Mutation, Missense
KW - Mycobacterium leprae
KW - Recurrence
AU - Cambau E
AU - Carthagena L
AU - Chauffour A
AU - Ji B
AU - Jarlier V
AB - <p>Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.</p>
BT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
C1 - http://www.ncbi.nlm.nih.gov/pubmed/16355335?dopt=Abstract
DA - 2006 Jan 15
DO - 10.1086/498506
IS - 2
J2 - Clin. Infect. Dis.
LA - eng
N2 - <p>Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.</p>
PY - 2006
SP - 238
EP - 41
T2 - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
TI - Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy.
VL - 42
SN - 1537-6591
ER -