TY - JOUR
KW - Concanavalin A
KW - Erythema Nodosum
KW - Humans
KW - leprosy
KW - Lymphocyte Activation
KW - Mitogens
KW - Mitomycins
KW - Mycobacterium Infections, Nontuberculous
KW - Mycobacterium leprae
KW - T-Lymphocytes, Regulatory
AU - Nath I
AU - Narayanan R B
AU - Mehra N K
AU - Sharma A K
AU - Gupte M D
AB - <p>Peripheral blood lymphocytes from nine normal subjects and 40 patients with leprosy were pretreated in vitro with Concanavalin A (Con A). Cells from normal subjects pretreated for 24 hours showed consistent and effective generation of suppressive activity which inhibited mitogen induced transformation of autologous lymphocytes. Prolongation of Con A pretreatment to 40 hours resulted in maximal suppressive activity. Tuberculoid leprosy patients had lymphocytes in their blood which on 24 hour pretreatment with Con A exerted suppressive effects markedly greater than the maximal suppression noted with 40 hour pretreated normal lymphocytes. In contrast, untreated patients with polar lepromatous leprosy showed a decrease in suppressive activity which could not be altered by prolongation of Con A pretreatment: the loss of suppressive activity noted in this form of leprosy was restored during erythema nodosum leprosum.</p>
BT - Journal of clinical & laboratory immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/161322?dopt=Abstract
DA - 1979 Nov
IS - 4
J2 - J Clin Lab Immunol
LA - eng
N2 - <p>Peripheral blood lymphocytes from nine normal subjects and 40 patients with leprosy were pretreated in vitro with Concanavalin A (Con A). Cells from normal subjects pretreated for 24 hours showed consistent and effective generation of suppressive activity which inhibited mitogen induced transformation of autologous lymphocytes. Prolongation of Con A pretreatment to 40 hours resulted in maximal suppressive activity. Tuberculoid leprosy patients had lymphocytes in their blood which on 24 hour pretreatment with Con A exerted suppressive effects markedly greater than the maximal suppression noted with 40 hour pretreated normal lymphocytes. In contrast, untreated patients with polar lepromatous leprosy showed a decrease in suppressive activity which could not be altered by prolongation of Con A pretreatment: the loss of suppressive activity noted in this form of leprosy was restored during erythema nodosum leprosum.</p>
PY - 1979
SP - 319
EP - 24
T2 - Journal of clinical & laboratory immunology
TI - Concanavalin A induced suppressor activity in human leprosy.
VL - 2
SN - 0141-2760
ER -